What constitutes “normal” 25(OH)D?

Over the past decade, we have learned that calciferol has a number of very important biologic functions beyond its skeletal effects. This was nicely reviewed in a recent Medical Progress report by Russell Chesney (J Pediatr 2011;156:698-703). This understanding has resulted in a number of studies examining the frequency of calciferol deficiency in various groups. A problem of these studies, however, has been defining “sufficiency” of this analyte. Studies that have used measures of bone turnover or parathyroid hormone as evidence of sufficiency may not reflect the levels that are “normal” for calciferol's non-skeletal effects. (Source: The Journal of Pediatrics)

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